Research

Scientific research has shown CBD may be therapeutic for many conditions. Relevant reports have been culled primarily from PubMed, online service of the U.S. National Library of Medicine, as well as articles and stories from general interest publications. Most of the PubMed material consists of abstracts on preclinical research involving single cannabinoid molecules, test tubes, petri dishes, animal experiments, and in some cases human cell line studies. Although all mammals have cell receptors that respond pharmacologically to cannabinoid compounds, data from animal experiments and other preclinical research is not always applicable to humans.

Most of the reports that follow pertain to Cannabidiol. Occasionally articles examine the therapeutic potential of other plant cannabinoids—THC, CBDA (cannabidiol in its raw acid form), THCV, CBG, and CBDV, for example. Included are also a few studies that illuminate various aspects of the endocannabinoid system without focusing on CBD.

Links are organized by condition.

GENERAL

• Safety and side effects of cannabidiol
• CBD: From an inactive cannabinoid to a drug with wide spectrum of action
• CBD as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
• CBD: An overview of some pharmacological aspects
• CBD: An overview of some chemical and pharmacological aspects
• The endocannabinoid system as an emerging target of pharmacotherapy
• Therapeutic potential of cannabinoid-based drugs
• Targeting the endocannabinoid system with cannabinoid receptor agonists
• Cannabis-based medicines–GW pharmaceuticals
• The therapeutic potential of cannabis and cannabinoids 
• Emerging strategies for exploiting cannabinoid receptor agonists as medicines
• Therapeutic potential of cannabinoid-based drugs
• Cannabinoids in clinical practice
• Cannabinoids
• Pharmacology of cannabinoids
• Combined cannabinoid therapy via an oromucosal spray
• Non-psychotropic plant cannabinoids
• Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology 
• Care and feeding of the endocannabinoid system
• Understanding the molecular aspects of THC and CBD as antioxidants 
• A tale of two cannabinoids 
• Clinical Studies With Cannabis and Cannabinoids, 2005-2009

ACNE

• The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content
• CBD as a Treatment for Acne?
• CBD exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease
• Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
• Endocannabinoid signaling and epidermal differentiation

ALZHEIMER’S DISEASE

• Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease
• The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
• Endocannabinoid signalling in Alzheimer’s disease
• A molecular link between the active component of marijuana and Alzheimer’s disease pathology
• Neuroprotective effect of CBD… on beta-amyloid-induced toxicity in PC12 cells
• The Potential Therapeutic Effects of THC on Alzheimer’s Disease
• The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease 
• Cannabinoids for the treatment of dementia
• CBD in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression 
• CBD: A promising drug for neurodegenerative disorders?
• Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
• The role of the endocannabinoid system in Alzheimer’s disease 
• The role of phytochemicals in the treatment and prevention of dementia 
• Cannabinoids for the treatment of dementia
• Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic